Hazard Identification and Characterization: Toxicological and Human Studies
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Asphalt Fume Characterization and Hazard Identification
RESEARCH SUMMARY: This research will be integral to development of sampling and analytical methods used to assess exposures to asphalt fumes and specific irritants and genotoxins. Laboratory research will be useful in designing better worker exposure protocols, identifying specific biomarkers to assess a worker's true exposure, and designing animal studies to evaluate physiological and toxicolo...
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Background: This study was conducted to identify and characterize repopulating spermatogonial stem cells (SSCs) in the adult human testes. Materials and Methods: Testes biopsies from obstructive azoospermic patients and normal segments of human testicular tissue were used. Flow cytometry, real time PCR and immunohistochemical analysis were performed. Purified human spermatogonia were transplant...
متن کاملThe analysis of hazard identification and risk assessment studies with the approach to assessing risk control measures since 2001 to 2017: A systemic review
Abstract background and aims: Nowadays the growing complexity of technology and industry has led to vast changes over the last few decades. These changes, in addition to their positive and valuable effects, have also caused industrial accidents affecting human life and the environment. According to the ILO 2011 report, there are 340 million annual workplace accidents and 160 million occupation...
متن کاملComparative toxicological pathology in mammals and fish: some examples with endocrine disrupters.
Toxicologic pathology is a classical discipline in the toxicology arena, and despite various emerging techniques, still is a major cornerstone in the process of hazard identification and risk characterization. Most knowledge derives from laboratory animal studies and, to a lesser extent, human data. Currently interest is growing in applying toxicological pathology for lower animals, in particul...
متن کاملToxicogenomic profiling of chemically exposed humans in risk assessment.
Gene-environment interactions contribute to complex disease development. The environmental contribution, in particular low-level and prevalent environmental exposures, may constitute much of the risk and contribute substantially to disease. Systematic risk evaluation of the majority of human chemical exposures, has not been conducted and is a goal of regulatory agencies in the U.S. and worldwid...
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